胃印戒细胞癌的胃镜及临床特点分析

Analysis of endoscopic and clinical features of signet ring cell carcinoma of stomach

目的 探讨胃印戒细胞癌的胃镜及临床特点。方法 将胃镜及病理证实的 10 4例胃印戒细胞癌与同期 75 6例其他类型癌进行对比分析。结果 胃印戒细胞癌好发于青年女性 (P <0 .0 5 ) ,内镜下胃印戒细胞癌侵犯胃体或 2处以上部位者明显多于其他类型癌 (P <0 .0 5 ) ,而侵犯胃底贲门者明显少于其他类型癌 (P<0 .0 5 )。肉眼分型Ⅳ型明显多于其他类型癌 (P <0 .0 5 ) ,Ⅰ型 ,Ⅱ型明显少于其他类型癌 (P <0 .0 5 )。临床以腹痛腹胀为主 ,其嗳气反酸 ,恶心呕吐及腹块腹水明显多于其他类型癌 (P <0 .0 0 5 )。结论 胃印戒细胞癌好于青年女性 ,易在胃壁弥漫浸润性生长 ,掌握胃印戒细胞癌的胃镜及临床特点 ,有助于早期诊断、早期治疗。

Objective:To investigative the endoscopic and clinical features of signet ring cell carcinoma of stomach.Methods: One hundred and four endoscopically and pathologically confirmed cases of signet ring cell carcinoma of stomach and 756 of other types of gastric cancer were cross-examined and analyzed. Results: Most patients with signet ring cell carcinoma of the stomach were young females ( P <0. 05). Under endoscope,there were more cases of one or more cancer impingement on stomach body than those of other types of gastric cancer ( P <0. 05),while cases of cancer impingement on stomach base and cardia were less than those of other types ( P <0. 05). Cases of gastric cancer Type IV was apparently more than those of other types ( P <0. 05). In contrast,instances of gastric cancer Type Ⅰ or Type Ⅱ were out numbered by those of other types ( P <0. 05). Abdominal pain was a primary clinical symptom. Other typical symptoms are belch,queasy acid-water,nausea,vomiting,abdominal lump and ascites ( P < 0. 05 ).Conclusion: Young females are prone to signet ring cell carcinoma of stomach, which easily find its way to the wall of stomach and permeate.A good knowledge of the endoscopic and clinical features of signet ring cell carcinoma of stomach would lead to early diagnosis and early treatment.