胶原酶溶解术治疗腰椎间盘突出症疗效与影像表现的关系

Correlative therapeutic effect and image feature in the treatment for lumbar intervertebral disc herniation with collagenase chemolysis

目的 评价胶原酶溶解术治疗腰椎间盘突出症后 1、2、3年的疗效 ,分析疗效与影像学表现的关系 ,为该方法筛选适应证的影像学表现。方法 按统一的诊断标准、治疗方法 ,对 1 996年 1月至1 999年 1月在我科行胶原酶溶解术的、资料完整的腰椎间盘突出症患者 1 2 5 4例进行随访观察 (复诊、书信、电话等方式 ) ,按统一的疗效标准评价胶原酶溶解术的 1、2、3年的疗效。结果 单纯性椎间盘突出症 ,1年优良率为 93.1 % ,2年优良率为 90 .3% ,3年优良率为 90 .9%。结论 单纯性椎间盘突出症是胶原酶溶解术的绝对适应证 。

Objective To evaluate the therapeutic effect of collagenase chemolysis after 1,2,3 years and analyse the relationship between the therapeutic effect and image features. Probing the image features for the indication, 1 254 patients with integral data who received collagenase chemolysis procedure were followed. Methods According to standard unification diagnostic criteria and therapeutic method, 1 254 patients with lumbar intervertebral disc herniation who had intergral data and received collagenase chemolysis from January 1996 to January 1999 in our department were followed up (by visit, letter or telephone call etc). The therapeutic effects of collagenase chemolysis after 1,2,3 years were evaluated with unified therapeutic effect criteria. Results For the simple lumbar intervertebral disc herniation, 1 year effective rate was 93.1%, 2 year effective rate 90.3% and 3 year effective rate 90.9%. Conclusions The simple lumbar intervertebral disc herniation is the absolute indication of collagenase chemolysis, but those combined with other factors dosen't adapt to collagenase chemolysis.