医用黏合剂ZT胶延缓碘化油在肝脏内代谢实验研究

Experiment research of ZT glue postpone iodinated oil metabolism in liver

目的 探讨医用黏合剂ZT胶在延缓肝脏内碘化油代谢过程的作用。方法 对 5只兔肝脏右侧门静脉插管 ,注射1 3 1 I 碘化油和ZT胶 ,γ定标仪连续纪录肝脏区域γ计数 ,建立1 3 1 I 碘化油的局部代谢方程 ,计算有效半排期 ;行病理学检查肝脏和肺脏。另 5只动物单纯注射1 3 1 I 碘化油 ,作为对照。结果 实验组1 3 1 I 碘化油的慢组份比例大于对照组 ,有效半排期延迟。右肝碘化油滞留量大 ,并对肝组织产生损伤。

Objective To study the ZT glue postpone iodinated oil metabolism in liver. Methods We had intubated into right portal veins for 5 rabbits, injected 131 iodine iodinated oil and ZT glue, successively recorded γ counts of liver region by γ calibration equipment, created local 131 iodine iodinated oil metabolism equation, calculated effective half drained times, and finally observed the liver and lung in pathology. Another 5 rabbits had been merely injected with 131 iodine iodinated oil as the control group. Results Experimental 131 iodine iodinated oil slow group was higher in proportion than the control group, with delaying of effective half drained times. 131 iodine iodinated oil had been retained more proportion within right liver causing damage to liver tissue. Conclusions ZT glue can postpone iodinated oil metabolism in liver.