摘要
目的 :研究卡铂 (CBP)加 5 -氟尿嘧啶 (5 FU) /醛氢叶酸 (CF)方案治疗晚期鼻咽癌的合适剂量、给药方法及客观疗效和毒副反应。方法 :前瞻性临床研究采用 5 FU 1 2 0h持续输注 ,同时每 4h口服CF 30mg联合CBP方案治疗晚期鼻咽癌 4 1例 ,3~ 4周重复 1次 ,至少用 2个疗程。结果 :4 1例患者共接受 1 5 5个疗程的化疗 ,其中CR 4例 ,PR 2 9例 ,NC 7例 ,PD 1例 ,有效率 80 5 % ;毒副反应主要为口腔炎、恶心和呕吐、骨髓抑制和脱发等 ,其余毒性均为Ⅰ~Ⅱ级 ,腹泻明显少且轻 ,骨髓耐受性好。结论 :5 FU 1 2 0h持续输注并服CF加CBP方案治疗晚期鼻咽癌 ,特别是对复治病变广泛者 ,疗效和安全性高 ,毒副反应小 ,患者可耐受 ,经济实用 。
Objective To explore the proper dosage,administrations,efficacy and side effects of curing advanced nasopharyngeal carcinoma (NPC) by means of carboplatin (CBP) plus 5 FU/CF.Methods The prospective clinical trial was carried out to treat 41 patients with NPC by continuous infusion of 5 FU for 120 hours,at the same time,taking CF30 mg every 4 hours combined with CBP.Treatments were repeated every 3-4 weeks,with no less than 2 courses.Results Forty one patients were given in total 155 courses of chemotherapy treatments.There were 4 cases of CR,29 cases of PR,7cases of NC and 1 case of PD,with the effective rate of 80.5%.The side effects mainly were:stomatitis,nausea,vomiting,arrest of bone marrow and alopecia,while the rest were toxicity stage Ⅰ-Ⅱ.Diarrhea became rare and the tolerance of bone marrow turned good.Conclusion The treatments for patients with advanced NPC by 120 hours continuous infusion of 5 FU and oral CF plus CBP,especially for patients with extensive pathologic change are very efficacious and safe,tolerant and economical,as well as of low side effects.It is definitely worth further research.
出处
《肿瘤防治杂志》
2003年第7期735-737,共3页
China Journal of Cancer Prevention and Treatment