砷化物治疗肿瘤的研究近况

Studies on Effect of Arsenical on Tumors

近年来临床研究表明 ,三氧化二砷 (As2 O3 )和四硫化四砷 (As4S4)对急性早幼粒细胞白血病有显著的疗效 ;有机砷美拉砷醇也试用于治疗难治或耐药的白血病患者。大量研究资料表明 ,As2 O3 、美拉砷醇、二硫化二砷 (As2 S2 )和As4S4等砷化物对各种血液肿瘤细胞和许多实体瘤细胞均有诱导凋亡和 或抑制其生长作用。As2 O3 治疗多发性骨髓瘤、慢性粒细胞白血病、骨髓增生异常综合征、原发性肝癌等某些实体瘤Ⅱ期临床研究均获得一定疗效。

Recent clinical studies show that arsenic trioxide(As 2O 3)and arsenic tetrasulfide(As 4S 4)are effective in the treatment to acute promyelocytic leukemia(APL).Moreover,melarsoprol(an organic arenide)is also used in the treatment of patients with refractory or resistant leukemia.As 2O 3,arsenic disulfide(As 2S 2),As 4S 4 and melarsoprol recently show that they can inhibit growth and/or induce apoptosis in various hematologic malignat cells and many solid tumor cells in vitro.As 2O 3 is an effective remedy to some extent for multiple myeloma,chronic myelogenous leukemia,myelodysplastic syndromes,cancer of the liver and a few of solid tumor in the phase Ⅱ studies.