马齿苋对家兔实验性动脉粥样硬化形成的作用

The Effect of Purslane on Experimental Formation of Atherosclerosis in Rabbits

目的 探讨马齿苋抗动脉粥样硬化 (AS)的作用 ,研究影响AS形成的有关因素。方法 动物分为A ,B ,C ,D 4组 ,A ,B ,C 3组建立动物高脂模型 ,B ,C组分别喂饲马齿苋干粉每天每只 8g或 12g ,实验 11周末 ,采血测定血脂、丙二醛、血液粘度等指标 ,用多元逐步回归分析 ,筛选影响AS形成的主要因素。结果 B ,C组与A组相比 ,血清总胆固醇 (TC)、甘油三脂 (TG)、丙二醛 (MDA)、全血低切表观粘度、血浆中切表观粘度水平明显下降 (P <0 .0 1) ,高密度脂蛋白胆固醇 (HDL C)明显上升 (P <0 .0 1) ,C组TC、全血低切表观粘度数值较B组明显降低 (P <0 .0 1) ,多元方程显示α =0 .0 5 ,0 .0 1时对Y有显著影响的是TC(X1) ,血浆中切表观粘度 (X6 )。马齿苋可明显阻止或降低血清TC ,TG ,MDA ,全血低切及血浆中切表观粘度的升高 ,并升高HDL C ,随着剂量的增加 ,马齿苋作用增强。结论 影响主动脉AS形成的主要因素是TC及血浆中切表观粘度 ,二者皆为正向影响 。

Objective To explore the effects of purslane on experimental formation of atherosclerosis forming in rabbits and to study relative factors affecting the formation of AS forming.Methods Rabbits were divided into 4 groups.The model of hyperlipidemia was established in groups A,B,C.Groups A,B,C were given 8 or 12 gram purslane/each animal for 11 weeks each day.Blood lipids,molondiadehyde(MDA) and blood viscosity were determined.Results Serum cholesterol(TC),triglyleride(TG),MDA,whole blood 3.75s -1 and plasma 37.5s -1 viscosities in groups B,C markedly decreased compared to A group(P<0.01);but HDL-C obviously increased(P<0.01).TC,whole blood 3.75s -1viscosity in group C were significantly lower compared to group B(P<0.01).Multiple regression analysis has suggested that TC, plasma 37.5s -1 viscosity have significant influence on AS.Purslane powder could markedly resfrain or lower TC,TG,MAD,whole blood 3.75s -1 and plasma 37.5s -1 viscosity,but raise HDL-C.With increase in the dose,the effect of puslane increased.Conclusion Multiple stepwise regression analysis has suggested that TC and plasma 37.5s -1 viscosity were primary factors affecting the formation of AS.