尿微量白蛋白测定在肝硬化肾实质损害中的意义

The Significance of Microproteinuria Measurement for Cirrhosis with Renal Lesion

目的 观察尿常规检查阴性肝硬化患者的肾实质损害情况。方法 采用双抗体夹心酶联免疫吸附法测定了 4 4例肝硬化患者和 2 6例正常人的尿白蛋白 (Alb)、β2 微球蛋白 (β2 M)。结果 所测尿微量蛋白肝硬化组显著高于正常对照组 (P <0 .0 1或 0 .0 5 ) ,肝功能ChildA ,B ,C级各组中浓度依次升高 (P <0 .0 5 )。结论 肝硬化患者可存在尿常规检查不能发现的肾小球和肾小管损害 ,肝功能越差损害越重 。

Objective To study the renal lesion of patients with cirrhosis whose urine routine test were negative.Methods Urinary albumin(Alb),β-microgloubulin (β 2-M) were measured in 44 patients with cirrhosis and 26 healthy people.Results Urinary levels of Alb andβ 2-M were significantly higher in cirrhosis group than that in control group (P<0.01 or 0.05),and became higher and higher in Child A,B and C stage(P<0.05).Conclusion There are glomerular and tubuler lesions in patients with cirrhosis whose urine routine test were negative.The microproteinuria measurement may be helpful to diagnose the early renal lesions of the patients with cirrhosis.