Survivin在骨肉瘤组织中的表达及其临床意义

Expression of survivin protein in osteosarcoma

目的探讨凋亡抑制蛋白survivin的表达与骨肉瘤组织生物学行为之间的关系。方法用免疫组织化学S-P法对42例骨肉瘤组织survivin蛋白的表达进行检测。结果42例骨肉瘤组织中survivin蛋白的表达率为64.3%,在对照组的10例骨软骨瘤组织中未见其表达;survivin的表达与Enneking分期有关(P<0.05),而与患者的性别、年龄、肿瘤部位、Price组织学分级及是否有软组织侵犯无关(P>0.05)。结论survivin基因可能在骨肉瘤的发生发展中起重要作用,可能为骨肉瘤的基因治疗提供了新的靶点。

Objective To investigate the expression of survivin in human osteosarcoma and its correlation with histobiological behavior.Methods The expression of survivin in42cases of human osteosarcoma were detected with immunohistochemistry by S-P method.Result The expression positi-vity rate of survivin was64.3%in osteosarcoma;no expression of survivin was detected in10cases of exostosis(as control group).The survivin expression was significantly associated with clinical stages(P<0.05),but not with sex,age,tumor locus,Price's grade and soft tissue invasion(P>0.05).Conclusion Overexpression of survivin in osteosarcoma may play an important role in tumorgenesis and tumor progression,and it may provide new target for gene therapy.