广东湛江围产期夫妇3766人地中海贫血性状和G6PD缺乏症的基因频率

GENE FREQUENCY OF THALASSEMIA CHARACTER AND G6PD DEFICIENCY OF 3766 PERINATAL PAIRS IN ZHANJIANG CITY OF GUANGDONG PROVINCE

采用高铁血红蛋白还原定性法,再用NBT定量法对湛江地区围产期夫妇3766人做了G6PD缺乏症基因频率的调查,对地中海贫血性状(杂合体)进行了筛查。结果示:该群体G6PD缺乏症基因频率为0.0508,介于广西钦州(0.0402)和海南白沙汉族(0.0638)之间。地中海贫血性状发生率为5.74％,其中α地贫约两倍于β地贫,而β地贫以HbA_2增高型多见。以该调查资料估算,湛江群体Bart's水肿胎发生率为0.036％,重型β地贫为0.01％。

Using methemoglobin reductive qualitative method and NET quantitative method,G6PD deficiency gene frequency of 3766 perinatal women-husbands in Zhanjiang district was investigated. The heterozygote character of thalassemia was also screened. The results showed that the gene frequency of G6PD deficiency is 0. 0508,that is between the Han people of Qinzhou, Guangxi ( 0. 0402) and Baisha , Hainan ( 0. 0638). The incidence of thalassemia character is 5. 74%, and the incidence of α-thalassemia is about twice as much as β-thalassemia. The HbA2 increasing type is more than other types in β-thalassemia. According to the data,the incidence of Bart's bydrops fatalis syndrome is about 3. 6×104,and the incidence of severe type of β-thalassemia is 1. 0× 104.