强力镇痫丸的药物毒理研究

Medicamentous toxicological study of Qiangli Zhenxian pill

目的 研究强力镇痫丸的药物毒性。方法 取健康昆明种小白鼠 2 0只 ,随机分 2组各 10只 ,给药组将 1/4强力镇痫丸溶解后灌胃 [相当于生药 15g/(kg·d)、成人用量的 10 0倍 ] ,和对照组一同于给药 3 0d和 60d时采血进行血常规以及肝肾功能检查。至喂药 60d时停药 ,继续饲养 3 0d将动物断头处死 ,取心、肝、肾组织行光镜检查。结果 小白鼠连续灌胃强力镇痫丸 3 0d和 60d及停药后 3 0d ,血常规、肝肾功能各项检查指标均无明显变化 ,与对照组相应指标比较无显著性差异 (P >0 .0 5)。动物的心、肝、肾组织经光镜检查未发现有毒性损害改变。结论 强力镇痫丸大剂量 (成人用量的 10 0倍 )、较长时间服用毒性低。

Objective It is to study the medicamentous toxicit y of Qiangli Zhenxian pill.Methods Twenty healthy Kunming rats were randomly divided into u sing drug group and control group. The rats in using drug group were given stomach-perfusion of 1/4 Qiangli Zhenxian pill [about 15 g/(kg·d) crude drug or 100 times than adul t] . Then blood routine, liver and renal functions of all rats in two groups were e xamined on the thirtieth day and the sixtieth day after the drug given. On the s ixtieth day the drug was stopped. The rats were killed with decapitation on the thirtieth day after the drug stopped. And then their heart, liver and renal tiss ues were examined under the light microscope.Results There were no changes in blood routine, liver and renal functions and ot her examinations on the thirtieth day and the sixtieth day after the drug given and on the thirtieth day after the drug stopped. There was no significant differ ence between the two groups (P>0.05). There were no poisonous damages in hea rt, liver and renal of the rats under the light microscope. Conclusion Big dosage and long time of Qiangli Zhenxian pill giv en is low toxicity and safe.