天麻钩藤饮对高血压肝阳上亢证大鼠一氧化氮、内皮素干预作用的研究

Experimental Study on Effect of Tianma Goutengyin on Nitric Oxide (NO) and Endothelin (ET) of Spontaneous Hypertension Rats (SHR) with the Syndrome of Exuberance of Liver Yang

目的探讨中药复方天麻钩藤饮的降压机理以及高血压肝阳上亢证与NO、ET的相关性。方法建立高血压肝阳上亢证模型,观察天麻钩藤饮对血清NO、血浆ET含量的影响。结果中药高剂量组与卡托普利组均能降低高血压肝阳上亢证大鼠血压;天麻钩藤饮能显著升高血清NO水平,且与剂量有关,但对ET无影响;肝阳上亢证大鼠血浆ET水平有升高趋势。结论影响NO水平变化可能是天麻钩藤饮的降压机制之一,ET升高可能是高血压肝阳上亢证的病理基础之一。

Objective To investigate the mechanism of Tianma Goutengyin reducing blood pressure (BP) and the relationship between the hypertension with the syndrome of exuberance of Liver Yang and NO, ET. Methods Construct a model of hyperdtension with the syndrome of exuberance of Liver Yang and observe the effect of Tianma Goutengyin on concentration of blood serum NO and plasma ET. Results Both Chinese medicine of high dose and Captopril can reduce BP of SHR with the syndrome of exuberance of Liver Yang. Tianma Goutengyin has the function of increasing singnificantly blood serum NO, but no effect on plasm ET of SHR with the syndrome of exuberance of Liver Yang have the tendency of ascension. Conclusions One of the mechanisims of Tianma Gotengyin to reduce BP may influent NO. Increasing ET is probably one of the pathological basis of hypertension of the syndrome of exuerance of Liver Yang.