OSAHS患者血清VEGF浓度变化及意义

Measurement of vascular endothelial growth factor in patients with obstructive sleep apnea hypopnea syndrome

目的 探讨血管内皮生长因子 (vascular endothelial growth factor,VEGF)在阻塞性睡眠呼吸暂停低通气综合征 (obstructive sleep apnea hypopnea syndrome,OSAHS)患者血清中的动态变化 ,讨论 VEGF动态变化的意义及与OSAHS病情的关系。方法 将 32例 OSAHS患者作为 OSAHS组 ,30例正常人为对照组 ,对所有受试对象做睡眠前 2 3:0 0和晨起 7:0 0时的血清 VEGF的含量测试 ,与对照组相比较 ,并与 OSAHS的病情进行相关性分析。结果 OSAHS患者在晨起 7:0 0时的血清 VEGF含量最高 ,明显高于对照组 ,高于睡前 2 3:0 0时血清 VEGF的含量 ,并且血清 VEGF含量与 OSAHS病情具有一定相关性。结论 OSAHS患者晨起血清 VEGF含量明显增高 ,OSAHS病情程度与 VEGF含量有密切关系 。

Objective To study the changes of the serum level of vascular endothelial growth factor (VEGF) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Serum level of VEGF at 7:00 AM and 23:00 PM was measured to analyse the correlation between VEGF level and OSAHS. Thirty two cases of OSAHS belonged to OSAHS group and 30 healthy people belonged to control group. Results The serum level for OSAHS patients at 7:00 AM was 243.598±47.65 pg/ml, for control subjects was 124.83±3.74 pg/ml (P<0.01). At 23:00 PM, the level for OSAHS patients was 161.31±21.73 pg/ml; for control group, 124.5±2.97 pg/ml ( P>0.05 ). The level of serum VEGF in OSAHS patients was higher at 7:00 AM, obviously higher than that in control people. ConclusionThe level of circulating VEGF in the morning in OSAHS patients is higher than that in controls and has a correlation with the degree of OSAHS.