引导组织再生术后屏障膜留置时间与牙周组织再生量的关系

Experimental observation of relationship between indwelling time of the barrier membranes and periodontal tissue regeneration after guided tissue regeneration treatment

目的:观察引导组织再生术(guidedtissueregeneration,GTR)后不同时期牙周组织的再生情况,以确定达到最大牙周组织再生量时屏障膜留置体内的合适时间。方法:将6只杂种狗的下颌双侧第二、三、四前磨牙制备慢性II度根分叉病变模型,一侧进行GTR治疗,另一侧只进行翻瓣术治疗,分别于术后第4,6,8周进行形态学和组织学观察。结果:GTR治疗组牙周组织再生量明显多于对照组,且GTR治疗后6周牙周组织再生量明显高于GTR术后4周(P<0.01),GTR治疗后第6周和8周之间差异无显著性意义。结论:GTR技术治疗II度根分叉病变患牙时,为达到最大牙周组织再生量所需要屏障膜的作用时间至少要6周。

AIM:To observe the periodontal tissue response to guided tissue regeneration(GTR) in different period in order to explore an appropriate indwelling time of the barrier membranes after GTR. METHODS:Six mongrels' grade II chronic furcation involvement was established, which had been created in all second,third and fourth premolar teeth of mandibular area.One side of the jaws were treated by GTR,and the other side were treated by flap operation therapy. The animals were sacrificed at 4, 6 and 8 weeks after operation,and routine histologic processing was performed. RESULTS:Comparing the two different treatments,there were more periodontal regenerative tissues in the GTR treatment groups than flap operation therapy group. Furthermore, in the GTR treatment group, the parameters of periodontal regeneration tissue in 6 weeks were significantly more than those at 4 weeks,while had no significant differences between 6 and 8 weeks. CONCLUSION:It spends at least 6 weeks in maintaining the barrier membranes staying in the furcation place in order to gain the most regeneration tissue,when GTP is used for the treatment of grade II chronic furcation involvement.