恒河猴细菌感染性子宫出血模型内膜螺旋动脉的形态学改变

Morphologic changes of endometrial spiral arteriolar in inflammatory metrorrhagia model of Rhesus monkey

目的 :从螺旋动脉的形态学角度研究恒河猴子宫炎性出血的机制。 方法 :选择月经正常的雌性育龄恒河猴 7只 ,随机分为模型组 4只和正常对照组 3只。模型组在月经第 3天行宫腔细菌接种 ,宫腔细菌接种后的第 4个月经周期分泌晚期取子宫内膜进行螺旋动脉的组织形态学检测。用正常恒河猴的子宫内膜作对照。 结果 :模型组子宫内膜螺旋动脉管壁变性严重 ,管腔扩张较明显 ,对照组为正常行经前期图像 ,螺旋动脉强烈收缩 ,内皮细胞无变性。 结论 :炎症因素导致的子宫异常出血与螺旋动脉收缩功能下降有关。

Objective: To investigate the relationship between inflammatory metrorrhagia and spiral arteriolar function. Methods:Seven normal menorrhea adult Rhesus monkeys were choosed and divided into model group and control group at random. Colon bacillus,staphylococcus aureus and peptostreptococcus were inoculated into uterine cavity of model group in the third day of menstruation. Then, the sample of endometrium is obtained in late secretory phase of the fourth menstrual cycle, which is examined under microscope. Endometrium of control group was not inoculated. Results:Compared with that of control group, the degenerative changes of spiral arteriolar wall were more severe and dilatation of lumen was more obvious. Conclusion:Inflammation-induced metrorrhagia might be correlated with poor contraction of spiral arterioles.