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结核分枝杆菌的分子生物学检测研究进展 被引量：4

The advance about study of molecular biology detection of Mycobacteria tuberculosis
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摘要 该文对用于结核分枝杆菌菌种及菌株鉴定的基因标记和序列作一综述。这些基因标记和序列包括插入序列、串联重复序列、存在于质粒pTBN12中的多态性GC丰富的重复序列、36bp顺向重复序列、间隔子寡核苷酸等。 This article reviewed the gene markers and the sequences for the detection of the species and strains of Mycobacteria tuberculosis. The gene markers and the sequences conclude insertion sequences, tandem repeat sequences, the polymorphic GC-rich repetitive sequences contained in the plasmid pTBN12, 36 bp direct repetitive sequences, spacer oligonucleotides.
作者 李子玲 刘忠令
机构地区 第二军医大学南京临床医学院 第二军医大学长海医院呼吸内科
出处 《医学研究生学报》 CAS 2004年第3期267-269,共3页 Journal of Medical Postgraduates
关键词 结核分枝杆菌 分枝杆菌 检测 Mycobacteria tuberculosis Mycobacteria Detection
分类号 R378.911 [医药卫生—病原生物学]
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参考文献21

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  • 2[2]Kivi M, Liu X, Raychaudhuri S et al. Determining the genomic locations of repetitive DNA sequences with a whole-genome microarray: IS6110 in Mycobacterium tuberculosis[J]. J Clin Microbiol,2002,40(6): 2192-2198.
  • 3[3]Sampson S, Warren R , Richardson M et al. IS6110 insertion in Mycobacterium tuberculosis:predominantly into coding regions[J]. J Clin Microbiol,2001,39(9):3423-3424.
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  • 6[6]Soolingen D, Hermans PWM, Haas PEW et al. Insertion element IS1081-associated restriction fragment length polymorphisms in Mycobacterium tuberculosis complex species: a reliable tool for recognizing[J].Mycobacterium bovis BCG,1992, 30(7):1772-1777.
  • 7[7]Kamerbeek J, Schouls L, Kolk A et al. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology[J]. J Clin Microbiol,1997,35(4): 907 - 914.
  • 8[8]Bauer J, Andersen AB, Kremer K et al. Usefulness of spoligotyping to discriminate IS6110 low-copy-number Mycobaterium tuberculosis complex strains cultured in Denmark[J]. J Clin Microbiol,1999,37(8): 2602-2606.
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医学研究生学报
2004年 第3期

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