多索茶碱缓释胶囊的制备与体外释放度考察

Study on Preparation and in Vitro Release of Doxofylline Sustained-release Capsules

目的 :制备多索茶碱缓释胶囊 ,考察其体外释放度。方法 :采用滚动成丸法 ,以微晶纤维素为种核 ,5 %羟丙基甲基纤维素为粘合剂 ,在包衣锅内将多索茶碱泛制成丸 ,再用EudragitRS100包衣 ,装胶囊。采用紫外分光光度法测定多索茶碱的溶出量 ,作为多索茶碱缓释胶囊的释放度测定指标。结果 :本法制备的缓释胶囊其释放度在2、6、10h时分别为20 %～40 %、40 %～80 %、80 %以上。结论 :制备工艺可行 ,重现性好 ,所制备的多索茶碱缓释胶囊体外溶出具有明显的缓释特性。

OBJECTIVE:To prepare the doxofylline sustained-release capsules and evaluate it's in vitro release.METH_ ODS:The doxofylline sustained pellets were developed by rolling technique and coated by Eudragit RS100.UV-spectropho tometry was adopted to determine the dissolubility of doxofylline,which marked the release profiles of that capˉsules.RESULTS:The dissolubilities of the capsules were20%～40%,40%～80%and more than80%at2h,6h and10h reˉspectively.CONCLUSION:The preparation procedure for doxofylline sustained-release capsules is feasible and repeatable.The capsules have obviously sustained property.