国产帕米膦酸二钠治疗非小细胞肺癌术后骨转移的临床研究

Treatment of Postoperative Bone Metastasis of Non-small Cell Lung Cancer with Domestic Pamidronate Disodium

目的 :评价国产帕米膦酸二钠对非小细胞肺癌术后骨转移的治疗作用。方法 :51例非小细胞肺癌行肺切除术后出现骨转移的患者随机分为两组 ,一组25例单用国产帕米膦酸二钠治疗 ,另一组26例在此基础上再加化疗。结果 :两组骨痛缓解率分别为68 0 %和69 2 % ,无统计学差异 (P>0 05) ;骨痛缓解的显效时间为2天～17天 ,平均4 1天。治疗后血清钙离子水平明显降低 ,34例同位素骨显像检查放射性浓聚显著降低。随访3月～2年半 ,仅2例发生骨折。结论

OBJECTIVE:To evaluate the therapeutic effect of domestic pamidronate disodium on postoperative bone metastasis in patients with non-small cell lung cancer.METHODS:25patients received only pamidronate disodium,26paˉtients with addition of combination chemotherapy.Follow-up was carried out in all patients.RESULTS:The pain relief rate was68.6%.The pain relief rates of pamidronate disodium and pamidronate disodium plus chemotherapy were68.0%and69.2%respectively with no significant difference(P>0.05).The effectual time for pain relief was2～17days(4.1days in avˉerage).Serum calcium level declined after treatment and reduction of bone radioactive isotope collection was found in34paˉtients.The follow-up periods ranged from3months to30months.Fratures were found only in two patients.CONCLUSION:Domestic pamidronate disodium has satisfactory therapeutic effect on postoperative bone metastasis of non-small cell lung cancer.