3-次苄基硫色满酮类化合物的合成及其体外抗真菌活性

Synthesis of 3-benzylthiochromanones and their in vitro antifungal activity

目的:设计合成3-次苄基硫色满酮类化合物,并对其抗真菌活性进行初步评价。方法:以取代苯硫酚为原料,经多步反应制得目标化合物,并采用琼脂2倍浓度稀释法测定目标化合物的抗真菌活性。结果:共合成了6个新化合物,经红外光谱、核磁共振氢谱及元素分析确证其结构。目标化合物对大部分供试真菌具有活性,但弱于对照品克霉唑。结论:3-次苄基硫色满酮在体外具有一定的抗真菌活性。

Objective:To synthesize 3-benzylthiochromanoes and measure their in vitro antifun-gal activity. Methods:Substituted thiophenols were used as starting material, the target compound was synthesized through several steps and their in vitro antifungal activity was studied. Results: 6 new compounds were synthesized and IR, 1H-NMR and elemental analysis were used to elucidate their chemical structure. Conclusions: The 3-benylthiochromanones synthesized have in vitro antifungal activity to most fungal strains tested.