抗真菌药的不良反应

The adverse drug reactions of antifungal agents

目前临床上许多疾病导致机体免疫力下降,真菌感染的发生率大大增加,使抗真菌药在临床得到越来越广泛的应用。大多数抗真菌药的特异性不强,作用于真菌的同时也易对宿主细胞产生毒性作用,不良反应成为限制抗真菌药在临床应用的重要因素。现概括介绍目前临床常用抗真菌药的不良反应。

Nowadays hypoimmunity cases were increasing because many clinical diseases could induce it and the incidence of fungal infections was greatly increased. Accordingly, clinical use of anti-fungal agents was wider and wider. Most antifungal agents didn't have specific selectivity in treatment of fungal infections. While fungi were killed, the host cells were also intoxicated. Therefore, ADRs of these agents was the vital factor to limit them uses. In this paper,the adverse reactions of antifungal a-gents commonly used were reviewed.