C反应蛋白检测在造血干细胞移植早期的应用研究

Study on Determination of C-reactive Proteinafter Hemopoietic Stem Cell Transplantation in Earlier Period

目的 :探讨血浆中C反应蛋白 (CRP)检测对造血干细胞移植早期合并症的诊断价值。方法 :动态检测 15例造血干细胞移植病员早期血浆中CRP的水平 ,并与临床早期各合并症相比较。结果 :发生感染时 ,血CRP明显升高 ,峰值均 >2 0mg/L ,且升高程度与感染程度正相关 ;无感染组其血CRP轻度升高 ,峰值均 <2 0mg/L。发生aGVHD时 ,血CRP水平无明显变化 ;发生VOD时 ,血CRP水平在原有水平上有下降。结论 :CRP检测是一项快速、有效的鉴别诊断造血干细胞移植早期合并症的指标。

Objective:To study the diagnostic value of complications of hemopoietic stem cell transplantation in earlier period by determination of plasma C-reactive protein(CRP).Methods:Plasma CRP levels were dynamically measured from 15 patients who had undergone hemopoietic stem cell transplantation in earlier period.The results were correlated with complications.Results:Plasma CRP levels were significantly higher in patients with infection(peak value>20mg/L)than those without infection(peak value<20mg/L).Plasma CRP levels rose gently in patient with acute graft-versus-host disease(aGVHD),Plasma CRP levels descended in patient with hepatic veno-occlusive disease(VOD).Conclusion:CRP determination is a rapid,useful index for diagnosis of complications of hemopoietic stem cell transplantation in earlier period.