100例高脂血症早期肾损害患者肾功能联检结果分析及治疗效果观察

Diagnoses value of the inspection of kidney function and treament of 100 patients with original hyperlipidemia combined early nephris

目的 探讨肾功能联检对原发性高脂血症早期肾损害的诊断价值及辛伐他汀和非诺贝特对高脂血症早期肾损害的治疗效果。方法 将 10 0例原发性高脂血症患者随机分为辛伐他汀组和非诺贝特组各 5 0例。两组患者均在服药前及服药后 8、2 4周查血脂及血 β2 - MG,取随意尿查 β2 - MG、Alb、Ig G(下称肾功能联检 ) ;并与 5 0例血脂正常的健康人 (对照组 )比较。结果 原发性高脂血症患者血、尿β2 - MG、尿 AL b及尿 Ig G均高于对照组 ,各指标均有显著性差异 (P<0 .0 0 1) ;与非诺贝特组比较 ,辛伐他汀组血清 TC、L DL - C明显降低 (P<0 .0 5 )。治疗后 8、2 4周辛伐他汀组血 β2 - MG,尿 β2 - MG、Alb、Ig G降低 ,与非诺贝特组比较 ,P<0 .0 1。结论 肾功能联检有助于早期发现原发性高脂血症亚临床肾脏损害 ;辛伐他汀在降低血 TC、升高 HDL- C的同时亦能降低 TG、尿蛋白 。

Objective To explore the diagnosis value of the inspection of kidney function to the early nephris of original hyperlipidemia and to verify the intervention effect of Simvastin and Fenofibrate to the early nephris of hyperlipidemia.Methods 100 patients with original hyperlipidemia were randomly divided into two groups.Simvastin and Fenofibrate were given repectively.TC,TG,HDL C,LDL C,β 2 MG of all from venous blood before and after using medicine 8 weeks,24 weeks,and after vegetarian 3 days.β 2MG,Alb,IgG of random urine were measured.Results The above indexes of blood and urine in patients with hyperlipidemia were higher than that of normal persons,and there is a remarkable difference in every index between them(P<0.001).Simvastin is better than Fenofibrate to debase hyperlipidemia,and the level of TC?HDL C had remarkable difference between Simvastin and Fenofibrate,P<0.05.The level of blood β 2MG and urine β 2MG ?Alb?IgG was obviously different between Simvastin and Fenofibrate group after 8 weeks,24 weeks,P<0.01.Conclusion The measurement of the inspection of kidney function contributes to finding the original nephris of hyperlipidemia early.Simvastin can reduce TC while reducing TG and raising HDL C.Simvastin can reduce urine Alb to protect kidney.