摘要
基因组研究表明 ,人类与黑猩猩和老鼠的基因序列 98%以上是相同的 ,是否是这 1%～ 2 %的基因的差异 ,就决定了人与黑猩猩和老鼠在表现型方面很大的差异 ?本文通过大量分析表明 ,由碱基 (5个 )→核酸 [DNA→RNA(mRNA、rRNA、tRNA) ]→氨基酸 (2 2种 )→蛋白质 (数百千种 )→染色体→基因组→性状 ,其遗传变异信息有逐级放大的过程。这是生物间基因序列虽然有 98%甚至 99%的相同 ,但表现型差异却较大的原因所在。基因序列完全相同 ,并不能说明基因功能相同 ,基因组研究的结果不能完全诠释基因功能表达的复杂过程。今后必将由序列基因组学→结构基因组学→功能基因组学→蛋白质组学深入发展 ,必须从网络层次研究基因表达 ,才能揭示生命的奥妙。另外我们使用的各种基因组研究技术和软件还有待改进 ,才能真正反映生物基因的差异。
The genomics study showed that, there were 98% gene sequences of human and chimp and mouse are the same, whether or not the larger difference between human and chimp and mouse was determined by the only 1%～2% gene difference? The conclusion could be got by large research results as fallows: the genetic variance enlarged from base(5)→nuclear [DNA→RNA(mRNA?rRNA?tRNA)]→amino acids(22)→proteins(hundreds and thousands)→chromosomes→genome→traits. Gene sequence is complete same,but that not mean the gene function is the same. The researches results of genome cannot complete explain the difference of gene expression and gene function. Genome will be developed deeply as from sequence genomics→structure genomics →function genomics→protomics. The life mystery would be explained by studying gene expression and by net analysis. At the end, the research results difference caused by genome study technology had been analyzed and discussed.
出处
《世界科技研究与发展》
CSCD
2004年第1期30-40,共11页
World Sci-Tech R&D
基金
国家自然科学基金 ( 3 0 2 70 82 1)
中国科学院择优支持 (STZ -0 1-12 )
中国科学院知识创新方向性项目资助
