中药女贞子化学成分的研究(Ⅰ)

Studies on chemical constituents of Fructus Ligustri lucidi(Ⅰ)

目的 :分析中药女贞子的化学成分。方法 :采用溶剂法和层析法分离、纯化女贞子的化学成分 ,并通过理化性质与光谱分析 ,鉴定所得化合物的分子结构。 结果 :从女贞子的乙醇提取物中分离得到 7个单体化合物 ,分别鉴定为齐墩果酸 ( )、木犀草素 - 7- O- β- D-葡萄糖苷 ( )、槲皮苷 ( )、β-胡萝卜苷 ( )、对羟基苯乙醇 - β- D-葡萄糖苷 ( )、甘露醇 ( )及己六醇( )。其中化合物 、 和 为首次从该植物中分离得到。结论 :分离并鉴定了女贞子的 7个水溶性化学成分 。

Objective: To study the chemical constituents of Chinese herb Fructus Ligustri lucidi , providing theoretic evidence for its exploitation and utilization. Methods: Chemical constituents of Fructus Ligustri lucidi were isolated and purified by solvent extraction and chromatography; their structures were identified by physiochemical properties and spectroscopic analysis. Results: Seven compounds were isolated from the ethanol extract of the fruits and identified as oleanolic acid(Ⅰ), luteolin 7 O β D glucoside(Ⅱ), quercitrin(Ⅲ), β sitosterol 3 O β D glucoside(Ⅳ), p hydroxyphenethyl β D glucoside(Ⅴ), D mannitol(Ⅵ) and hexitol(Ⅶ). Compounds Ⅱ,Ⅲ and Ⅶ were obtained from this plant for the first time. Conclusion: Seven compounds have been obtained from the title plant, which provides a base for its future use.