健脾活血中药联合谷胱甘肽防治肝癌化疗栓塞术后肝功能损害的临床研究

CLINICAL STUDY ON LIVER’S FUNCTION INJURY AFTER TRANSCATHETER ARTERIALCHEMOEMBOLIIATION IN HEPATOCELLULAR CARCINOMA PREVENTED WITH STRENGTHENINGSPLEEN AND ACTIVATING BLOOD CIRCULATION HERBS AND GLUTATION

目的 :观察健脾活血中药联合谷胱甘肽对防治肝癌化疗栓塞术 (TACE)后肝功能损害的疗效。方法 :6 4例中晚期肝癌患者随机分为治疗组和对照组 ,治疗组在TACE前后均服用健脾活血为主的中药 ,同时给予谷胱甘肽 1 2g静滴。对照组给予肝泰乐和肌苷护肝。两组病例分别检查肝功能。结果 :治疗组血清谷丙转氨酶 (ALT)、γ -谷氨酰转肽酶 (GGTP)、总胆红素 (TB)和直接胆红素 (DB)均较治疗前无明显改变或只有轻微升高 ,P >0 0 5 ;对照组则有明显变化 ,ALT、GGTP、TB和DB均较治疗前升高 ,P <0 0 1。结论 :健脾活血中药联合谷胱甘肽可防治肝癌TACE后所引起的肝功能损害。

Objective:To evaluate the effect of Chinese herbal medicines combined with Glutathion in treatment of liver function injury after transcatheter arterial chemoembolization (TACE).Methods:Sixty-four cases with advanced hepatocellular carcinoma were divided into two groups:group A(n=34) and group B (n=30).Strengthening the spleen and activating blood circulation Chinese herbs were used in group A before and after TACE,added some other Chinese medicines according to the symptoms and Glutathion after TACE.Glucurolactone and Inosine were used in group B before and after TACE.Liver function was measured in both group A and group B before the first TACE and one month after first and second TACE respectively.Results:In group A,compared with that before TACE,there were no statistically changes(or only a mild rise)in ALT,GGTP,TB and DB after the first and second TACE( P >0 05),and oppositly in group B( P <0 01).Conclusions:strengthening the spleen and activating blood circulation Chinese herbal medicines combined with Glutathion can prevent liver function injury after TACE.