急性白血病患儿血浆内皮素变化及其临床意义的探讨

The level of endothelin in children with acute leukemia and its clinical sienificance

目的 探讨AL患儿血浆ET变化的临床意义。方法 采用放射免疫法检测2 0例健康儿童和 41例急性白血病 (AL)患儿血浆内皮素 (ET)水平。结果 急性白血病发病组血浆ET平均值为 95 .15ng/L ,明显高于健康儿童对照组 3 9.95ng/L(P <0 .0 1)。经化疗缓解后血浆ET平均值降至正常水平 (3 8.3 0g/L) ,明显低于未缓解组血浆ET平均值 95 .15ng/L(P <0 .0 1)。AL患儿血浆ET值与骨髓白血病细胞数量呈正相关 (r=0 .93 89,P <0 .0 1) ,结论 动态观察患儿血浆ET水平对判断急性白血病的病情与预后有重要意义。

Objective To explore the clinical significane of the level of plasma endothelin in children with acute leukemia. Methods The level of plasma endothelin (ET) were determined by RIA in 20 healthy individuals and41 children with acute leukemia (AL) including 15 patients in complete remission(CR) group and 26 in none remission(NR). Results The mean of ET in AL group(95.15 ng/L) was significantly higher than that of the healthy group (39.95 ng/L, P<0.01 ). The level of ET in CR group (38.30 ng/L) wasapparently lower than that of the NR group (95.15 ng/L, P<0.01) and the normal range.