环磷腺苷-葡甲胺治疗肺心病心肺功能不全的临床研究

Effect of Xinxianan injection on the lung and heart function in chronic Cor Pulmonale patients

目的 :观察环磷腺苷 -葡甲胺 (葡甲胺 - c AMP)对肺心病失代偿期心肺功能不全的疗效。方法 :使用环磷腺苷 -葡甲胺合并常规疗法治疗肺心病心肺功能不全患者 5 12例 (治疗组 ) ,观察患者治疗前后肺功能、心电图、动脉血气变化 ,同期对比观察安慰剂合并常规治疗 2 73例 (对照组 )。结果 :治疗组总有效率和显效率分别为 92 .2 %和 73.8% ,明显高于对照组 73.6 %和 4 9.5 % ( P <0 .0 5 )。两组治疗后 VC、FEV1 和 PEF、Pa O2 均明显增加 ,治疗组更显著 ( P <0 .0 5 )。治疗组心电图有效率为 6 3.7% ,明显高于对照组 4 1.2 % ( P <0 .0 5 )。两组均未见明显的不良反应。结论 :环磷腺苷 -葡甲胺可改善肺心病患者的心肺功能。

Object: To observe the effect of Xinxianan injection on the lung and heart function in patients with chronic Cor Pulmonale. Methods: 512 patients with Cor Pulmonale in the Xinxianan group treated with Xinxianan injections and regular treatments were observed. Their clinical presentation, arterial gas analysis, pulmonary function and ECG were examined before and after treatments. The results were compared with those of 273 patients with placebo and regular treatments. Results: In Xinxianan group, the total effective rate(92 2%) and markedly effective rate (73.8%) were significantly higher (P<0.05) than those in control group (73.6%, 49.5%).Compared with the control group, the pulmonary function of VC?FEV 1 and PEF, the arterial PaO 2 were obviously improved in treated group(P<0.05). After Xinxianan treatments, the ECG also improved significantly(P<0.05). No obvious side effects were observed in the treatments. Conclusion: Xinxianan injection can improved lung and heart function in patients with chronic cor pulmonale.