榄香烯及5-氟脲嘧啶生化调节方案治疗胃肠道腺癌临床疗效观察

Clinical observation of elemene injection combined 5-Fu biochemical adjustment therapy on gastrointestinal adenocarcinoma

目的 :观察榄香烯及 5 氟脲嘧啶 (5 Fu)生化调节方案治疗胃肠道腺癌患者的临床疗效。方法 :采取随机分组法将 6 0例胃肠道腺癌患者分为对照组和观察组。对照组 2 0例 ,给予 5 Fu及顺氯氨铂 (DDP)单纯化疗。观察组 4 0例 ,给予榄香烯联合 5 Fu/DDP化疗 ,观察 1个疗程。治疗前后分别检查血常规、肝肾功能、TC亚群和自然杀伤细胞活性 ,观察肿瘤病灶大小变化 ,同时记录临床症状变化及化疗毒副反应。结果 :观察组及对照组癌灶缓解率分别为 4 2 .5 %和 2 5 % ,两组间存在显著性差异 (P <0 .0 5 )。在改善临床症状、提高生存质量及免疫功能等方面 ,观察组均显著优于对照组 (均P <0 .0 1)。结论 :榄香烯联合化疗的疗效较单纯化疗好 ,可减轻化疗毒副反应 ,提高患者的免疫功能和生存质量。

Objective:To study the effects of elemene injection combined 5-Fu biochemical adjustment therapy to clinical symptoms, functions of anti-cancer and immunization of gastric and colon cancer.Methods:60 cases were randomly divided into two groups, there were 20 cases in group A which treated with chemotherapy (5-Fu/DDP)for one course while there were 40 cases in group B treated with 5-Fu and elemene injection combined chemotherapy for one course. BRt, function of liver and kidney,CD_4/CD_8 and activity of NK celles were examined before and after treatment.Tthe changes of cancer focus size,clinical symptoms, qualities of life, toxic and side effects were recorded and compared.Results:The relief rates of cancer focus in group A and group B were 25% and 42.5% with significant difference ( P <0.05). The responses of clinical symptoms, qualities of life and immunization function in group B were befferthan group A with significant difference ( P <0.01).Conclusion:The treatment effects of group B (elemene Injection+5-Fu/DDp) are better than group A' s (5-Fu/DDp), the plan of group B could reduced toxic and side effects of chemotherapy, increases CD4/CD8,stimulates the activity of NK celles and improves qualities of life.