日光照射诱发的系统性红斑狼疮的研究

Study on Systemic Lupus Erythematosus Induced by Sunlight

目的 探讨日光照射诱发的系统性红斑狼疮 (SLE)的临床特点。方法 分析 5 2例对日光过敏的由日光照射诱发的SLE患者及 40例无日光过敏的SLE患者的临床资料。结果 日光照射诱发的系统性红斑狼疮患者其首发症状以关节痛和面部红斑为主 ,而无日光过敏的SLE患者其首发症状以肾脏病变和关节痛为主 ,日光照射诱发的SLE患者颧部红斑、抗ds -DNA抗体阳性率明显高于无日光过敏组SLE患者 (P <0 0 1)。而心包炎、胸膜炎、肾脏病变、贫血低于无日光过敏的SLE患者 (P <0 0 1)。两者口腔溃疡、关节炎、神经系统病变、白细胞减少、血抗Sm抗体及抗核抗体阳性率无明显差异。

Objective To explore the clinical features of systemic lupus erythematosus (SLE) induced by sunlight.Methods The clinical data of 52 patients with SLE induced by sunlight and 40 SLE patients without photosensitivity were analyzed. Results Compared with SLE patients without photosensitivity, malar rash and anti-ds-DNA antibody in patients with SLE induced by sunlight were more common,which pleuritis, pericarditis, renal disorder and hemolytic anemia were less frequency. There were not significant differences in oral ulcers, arthritis, neurologic disorder, leukopenia, positive anti-Sm antibody and antinuclear antibody between the two groups patients. Conclusion We should pay more attention to the clinical features of SLE induced by sunlight.