前额叶皮质损伤患者的情绪异常

Emotional Disorders in Patients with Prefrontal Cortex Lesions

人类前额叶皮质与情绪之间有着密切的关系,文章在相关的临床和神经成像研究结果基础上,分析了前额叶皮质损伤对情绪行为造成的影响,分别概述了精神分裂症、重性抑郁和焦虑患者的情绪变化、前额叶切除对情绪的影响以及左右前额叶皮质与情绪的关系,重点阐述了前额叶功能异常的神经生理学特点,认为情绪的改变会随着前额叶皮质不同部位的结构缺损或功能变化而有所不同,此有利于对前额叶皮质损伤患者情绪异常的评价与防治。

A strong association between the prefrontal cortex in the brain and human emotion has been recognized. The effect of prefrontal cortex damage on emotional behavior has been abbreviated reviewed with pertinent clinical and neuroimaging observations in the past. Three clinical syndromes characterized by mood disorders, those are schizophrenia, major depression and anxiety disorders etc. They are dependent upon frontal system, especially prefrontal cortex dysfunction. There is convincing evidence that different facets of affective functioning, the experience of emotion, the expression of emotion, and the processing of emotionally laden information have distinct neural representation of prefrontal cortex.