大剂量沐舒坦对急性呼吸窘迫综合征患者抗氧化能力的影响

The effect of high dose ambroxol on the antioxidant activity in patients with ARDS

目的 研究大剂量沐舒坦对急性呼吸窘迫综合征 (ARDS)患者抗氧化能力的影响。方法 选择ARDS患者 4 2例 ,随机分成对照组 (A组 ,n =2 0 )和观察组 (B组 ,n =2 2 )。A组每天给予单纯生理盐水 5 0 0ml静脉滴注 ,B组每天给予沐舒坦 2 0mg/kg加生理盐水 5 0 0ml静脉滴注 ,连续应用 7d。比较两组患者在肺损伤程度、血气指标和血清超氧化物歧化酶 (SOD)活力等方面的变化和差异。结果 用药后B组患者的血气指标和肺损伤评分明显改善 ,血清SOD活力显著升高 (P <0 0 5或P <0 0 1) ,与A组比较均有显著性差异 (P <0 0 5或P <0 0 1)。结论 临床应用大剂量沐舒坦可增强ARDS患者的抗氧化能力 。

Objective To investigate the effect of high dose ambroxol on the antioxidant activity in patients with ARDS.Methods 42 patients with ARDS were divided randomly into two groups.Patients in group A were treated only by 0.9%NaCl(500 ml),and in group B with high dose ambroxol (20 mg/kg) plus 0.9% NaCl (500 ml) once a day for 7 days.The blood samples for blood gas analysis and SOD measurement were taken before the infusion.on the 5 th day and on the 7 th day of the infusion respectively. Outcome of patients in both groups including various pulmonary function indices was analyzed. Results The pulmonary function indices and the SOD activity of the patients in group B were improved significantly (P<0.05 or P<0.01),which were much better in group B than those in group A (P<0.05 or P<0.01).Conclusion Ambroxol could enhance the ability against superoxide injury and improve pulmonary function in patients with ARDS.