摘要
目的 :探讨厄贝沙坦对肾切除加重复阿霉素注射的方法复制的肾小球硬化模型大鼠肾组织肝细胞生长因子 (HGF)分泌的调节。方法 :将肾小球硬化大鼠分为厄贝沙坦治疗组和对照组 ,设假手术组为正常对照。检测厄贝沙坦治疗 8周后的肾功能和组织病理改变 ,用免疫组化方法检测肾小球和肾小管 间质中HGF的表达 ,并用ELISA法比较各组大鼠肾组织分泌的HGF。结果 :厄贝沙坦治疗组较对照组肾组织HGF的表达增加 ,肾组织分泌的HGF含量增加。结论 :厄贝沙坦可以上调肾组织HGF的分泌 ,加强HGF的肾保护作用 ,延缓肾小球硬化 ,减轻肾小管 间质纤维化。
Objective: To investigate the effect of irbesartan on renal expression of hepatocyte growth factor(HGF) in glomerular sclerosis in rats which were induced by unilateral nephrectomy followed by double intravenous injection of adriamycin. Methods: The rats were randomly divided into three groups:normal group,control group and irbesartan treatment group. Rats with sham operation served as normal control group. After 8 weeks'treatment,the renal function and histopathological changes were evaluated. Immunohistochemistry was used to examine the expression of HGF in renal tissue. And excretion of renal HGF was compared by ELISA. Results: The expression and excretion of renal HGF in irbesartan treatment group was significantly higher than that in control group. Conclusion: Irbesartan can up-regulate the renal HGF,strengthen its renotrophic function and retard the development of glomerular sclerosis and tubulointerstitial fibrosis.
出处
《武汉大学学报（医学版）》
CAS
2004年第2期137-140,共4页
Medical Journal of Wuhan University
