1-(四氢呋喃-2-基)-3-[4-(O,O-二烷基硫代磷酰基,S-亚甲基羰基氧代)丁基]-5-氟尿嘧啶的合成

Synthesis of 1-(tetrahydrofuran-2-yl)-3--5-fluorouracil

替加氟——1-(四氢呋喃-2-基)-5-氟尿嘧啶作为5-氟尿嘧啶的衍生物是目前临床使用的抗肿瘤药物，但由于其脂溶性小、选择性较差、毒副作用较大而限制了它的广泛使用．为了提高其疗效，降低毒副作用，对其结构修饰一直是人们研究的热点^[1]．

The title compounds were prepared by the reactions of 1-(tetrahydrofuran-2-yl)-3--5-fluorouracil with O,O-dithiophosphoryl acetic acids. The structures of the title compounds were confirmed by IR, MS, ()~1H NMR spectra and elemental analysis.