电针对实验性心绞痛时心肌氧代谢和冠状脉窦血液酸碱度的影响

EFFECT OF ELECTROACUPUNCTURE ON MYOCARDIAL OXYGEN METABOLISM AND PH OF CORONARY SINUS BLOOD DURING EXPERIMENTAL ANGINA PECTORIS

冠心病心绞痛主要是由于冠脉血流减少,心脏血氧供应不能满足心脏的代谢需要而引起的。血氧供应不足时,心肌的代谢会发生一系列改变,酸性代谢产物增加,导致缺血局部pH值降低。

The experiments were performed on 30 healthy mongrel dogs,intubation was taken in the left anterior descending coroniary (LAD), the blood in carotid was tran-sported to LAD through a peristalic pump, the blood flow was reduced to 3-5tnl/min, thus acute myocardial ischemia was produced. Basing on this condition, 0.1-0.16ml bradykinin (2ug/ml) was gived into LAD coronary before recording to produce angina pectoris. The effects of electroacupuncture(EA) at 'Neiguan' area on myocardial oxygen metabolism, pH of coronary sinus blood and myocardial contractile force were observed (EA intensity 5 volts, frequency 1-20 Hz). The results are as follows: 1. EA could reduce obviously A-V difference of blood oxygen capacity (Ca-vO_2) and the rate of myocardium extracting oxygen (O_2E), thus reduced obviously oxygen consumption of ischemic myocardium. 2. EA could reduce V-A difference of carbon dioxide partial pressure (PvaCO_2), prevent the decrease of pH of coronary sinus blood (PHv), this indicated that EA could prevent accumulation! of acidic metabolic products. 3. EA could increase myocardial developed tension (DT) of ischemic area, strengthen myocardial contractile force of ischemic area. Above results indicated that EA could reduce oxygen consumption of ischemic myocardium, prevent the decrease of pH of coronary sinus blood, thus myocardial cell acidosis was prevented, myocardial contractile force was strengthened. It might be the mechanism of acupuncture treating coronary heart disease.