哮喘家系成员血清总IgE的遗传学分析

Genetic analysis of serum total IgE of pedigree member in asthma

目的 探讨哮喘家系成员血清总IgE的遗传方式。方法 收集哮喘遗传家系 ,用酶联免疫吸附测定方法检测哮喘家系成员病人和正常人的血清总IgE ,并取无哮喘家族史和无过敏家族史的正常人作为对照组 ,进行总IgE的遗传分析。结果 哮喘家系成员的血清总IgE分布是双形态分布 ,父母一方及其子女IgE超常的占 5 6 % ,父母双方及其子女IgE超常的占5 0 %。结论 总IgE可能是以单基因遗传控制为主 ,且总IgE的超常 (H)

Objective To study the genetic pattern of serum total IgE in asthmatic pedigree. Methods To test serum total IgE with ELISA in asthmatic pedigree member, genetics pattern of serum total IgE was analysed. Results The figures of frequency distribution of serum total IgE were bimodal. Children whose parents or parent possesed higher level total IgE had higher level total IgE (above 50%). Conclu- sions Serum total IgE may be controlled by single major gene. Inheritance of higher level serum total IgE may be autosomal dominant and accompanied by incomplete penetrance.