内源性一氧化氮与食道静脉曲张程度的关系及意义

Relation of the endogenous nitric oxide and esophageal varices and its clinical implications

目的 探讨内源性一氧化氮与肝硬化食道静脉曲张的关系及临床意义。方法 检测 76例肝硬化合并食道静脉曲张 (EV)患者的一氧化氮 (NO)、内毒素 (LPS)水平 ,分析了轻、中、重度EV时NO、LPS的水平及意义。并对NO与食道胃底静脉破裂出血、LPS的相关性以及LPS血症的发生率进行了分析。结果 肝硬化患者NO、LPS显著升高 ,并与EV的轻重有显著相关性 ;高NO组消化道出血发生率明显增高 ;NO与LPS呈明显相关性 ;内毒素血症发生率随EV的加重而增加。结论 NO的升高与EV互为因果 ,降低NO、LPS治疗对肝硬化食道静脉曲张有益。

Objectives To study the relation of nitric oxide and the esophageal varices (EV) and its significance. Methods The serum nitric oxide (NO) and endotoxin (LPS) were measured in 76 patients with liver cirrhosis,and its clinical significance were analysed in the patients with light,middle,severe esophageal varices. The relation of NO and esophageal varices bleeding,LPS accidence of endotoxema were studied. Results The NO and LPS obviously increased in cases with liver cirrhosis,and appeared significant correlation to EV degree;The accidence of bleeding in the patients with high NO level were apparently increased;Endotoxema always accompanied EV aggravating. Conclusions The NO and EV enhanced each other in patients with liver cirrhosis. Decreasing NO and LPS was beneficial to EV. =