肾移植术后吗替麦考酚酯替换硫唑嘌呤疗效观察

Conversion from azathioprine to mycophenolate mofetil in renal transplant recipients

目的 初步探讨肾移植后吗替麦考酚酯 (MMF)替换硫唑嘌呤 (Aza)的安全性及其临床效果。方法 回顾分析 16例由Aza转换为MMF的患者的临床资料。 4例因肝功能损害而改用MMF ,7例肾功能损害 ,5例应患者本人要求而换用MMF。结果 4例肝功能损害者肝功能均恢复正常 ,7例肾功能损害者 2例逆转 ,4例肌酐 (SCr)下降但未能恢复正常 ,1例继续恶化恢复血液透析。副作用包括 2例出现原有贫血明显加重 ,1例腹泻。结论 Aza可以安全替换为MMF ,因CsA +Aza引起肝功能损害者 ,换用MMF ,减少CsA用量 ,肝功能可望恢复 ,MMF对部分慢性排斥反应可能有效。

Objective To evaluate the safety and efficacy of the conversion from azathioprine (Aza) to mycophenolate mofetil (MMF) in renal transplant recients.Methods 16 cases were retrospectively analyzed. The conversion caused by liver function destruction (4 cases),renal function destruction (7 cases) and recipients request (5 cases) respectively.Results All the patients with hepatic function destruction recovered. The serum creatinine(Scr) of the patients with impaired renal function was reduced to normal level in 2 cases,decreased in 4 cases. Conclusion Conversion from azathioprine to mycophenolate mofetil in renal transplant recipients are safe and effective.