摘要
本文用X-射线衍射法测定了具有抗癌活性的化合物道孚香茶菜乙素C_(24)H_(32)O_7的晶体和分子结构。该晶体属正交晶系,空间群为P2_12_12_1;晶胞参数为:a=7.981(2),b=11.338(5),c=25.059(12)A;z=4。R因子为0.0736。分子中含有α-亚甲基环戊酮五员环,因具有较大的内应力,使其具有杭癌活性。
Dowensin B extracted from Rabdosia dowoensis Hara is a kind of the anticancer-actire compound. Its crystal and molecular structure has been determined by X-ray diffraction method. The crystal is orthormbic,belonging to space group P2_12_12_1 ,and the cell parameters are a= 7. 981 (2) ,b= 11. 338 (5) ,c = 25. 059 (12) A,Z = 4. The final R-factor equals 0. 0736 for 1574 relection with |F_0|≥3σ(|F_0|). In the molecule there is α-methylene-cyclopentanone 5-membered ring,which is a antieancer-active zone owing to its angle strain.
出处
《郑州大学学报（自然科学版）》
CAS
1992年第2期65-69,共5页
Journal of Zhengzhou University (Natural Science)
基金
山东大学晶体材料实验室开放课题
关键词
道孚香茶菜
晶体结构
二萜化合物
dowoerlsin B
X-ray diffraction
crystal structure
molecular strcture
a-methylene-cyclopentanone
