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WT1基因在肾脏疾病中的表达及意义 被引量:2

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摘要 WT1 是一个位于 11号染色体短臂 1区 3带的抑癌基因 ,目前研究表明WT1 的主要功能是识别、结合特异的目标DNA并调节转录。WT1 在成熟肾脏的肾小球的足细胞中表达。某些肾脏疾病已发现WT1 的表达减少。提示WT1 基因可能与肾脏疾病的发生、发展及预后有关。
出处 《国外医学(泌尿系统分册)》 2004年第2期287-289,共3页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
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同被引文献19

  • 1敖绪军,张璟.HGF抗肾脏纤维化机制的研究进展[J].国外医学(生理病理科学与临床分册),2005,25(3):227-229. 被引量:7
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  • 8Wang ZY, Qiu QQ, Deuel TF. The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains [J]. J Biol Chem,1993, 268(13):9172-5.
  • 9邓莉莉,张玲.BMP-7在抑制肾脏纤维化中的作用[J].生命的化学,2007,27(5):439-441. 被引量:1
  • 10Levey AS,Atkins R,Coresh J,et al.Chronic kidney disease as a global public health problem:Approaches and initiatives-a position statement from kidney disease improving global outcomes[J].Kidney Int,2007,72(3):247-259.

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