香芍胃药胶囊抗大鼠溃疡作用

Anti-gastric-ulcer Action of Xiangshao Capsule in Rats

目的观察香芍胃药胶囊对胃溃疡动物模型的治疗保护作用,并初步探讨可能的机制。方法将动物随机分为6组:模型组、洛赛克组、三九胃泰组、香芍胃药胶囊低、中、高剂量组。按照传统方法造模、给药,然后观察溃疡点数,测定胃酸量、胃酸酸度、胃蛋白酶含量,并与对照组比较。结果香芍胃药胶囊能抑制大鼠幽门结扎型溃疡的形成,抑制胃液的分泌,降低总酸及胃蛋白酶排出量;促进乙酸烧灼型胃溃疡的愈合。结论香芍胃药胶囊对胃溃疡有不同程度的防治作用,其作用机制可能与该药能减少胃液分泌、减少总酸及胃酶排出量有关。

Objective To assess the protective effect of Xiangshao Capsule on gastric ulcer of rats,and to explore its possible therapeutic mechanism.Methods Rats were randomized into 6 groups:control group,Lusaike group,Sanjiuweitai group,Xiangshao capsule groups (low,moderate and high dose respectively).Rat models of gastric ulcer were established with the traditional methods.After modeling and treatment,the spots of ulcer were counted;the volume of gastric acid juice,gastric acidity,pepsin content and activity were determined.Results Xiangshao Capsule inhibited the development of gastric ulcer of rats induced by pyloric ligation,promoted the healing of gastric ulcer induced by acetic acid,decreased the secretion of the gastric juice and the output of total gastric acid and pepsin.Conclusion Xiangshao Capsule has effects in preventing and treating gastric ulcer and the mechanism may be related to the decrease of gastric juice secretion and the output of total gastric juice and pepsin.