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超临界状态下压力对穿心莲内酯萃取结晶的影响 被引量:2

Effect of pressure in supercritical state on extraction and crystallization of andrographolide
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摘要 目的 利用超临界 CO2 萃取结晶技术纯化穿心莲内酯。方法 采用系统观察法考察了超临界 CO2 萃取结晶分离对穿心莲内酯晶体形态、纯度、结晶量的影响 ,并采用扫描电镜、HPL C法分析结果。结果 穿心莲内酯晶体形态随压力的升高而变细、变短 ;随着压力的升高 ,晶体纯度提高 ,结晶量增加。结论 超临界 CO2 能萃取并同步高效结晶分离穿心莲内酯 ,为开发高质量中药活性成分提供一条捷径。 Object To separate and purify andrographolide by supercritical CO 2 extraction and crystallization. Methods The method of systematic observation was used to investigate the crystal appearance, purity and mass of andrographolide by supercritical CO 2 extraction and crystallization, analyzing by scanning electron microscope (SEM) and HPLC. Results The higher the pressure, the smaller and shorter the crystal shape, and the purer the purity, the more the mass of andrographolide. Conclusion This technique is a innovation of traditional supercritical fluid extraction (SCFE) technique, which realizes highly effectual separation of andrographolide by supercritical CO 2 extraction and synchronous crystallization, developes a new technology to separate andrographolide and other active ingredients from Chinese traditional herbs.
出处 《中草药》 CAS CSCD 北大核心 2004年第3期262-264,共3页 Chinese Traditional and Herbal Drugs
基金 国家自然科学基金资助项目 (2 99760 0 8)
关键词 穿心莲内酯 超临界CO2 流体萃取 结晶 andrographolide supercritical CO 2 fluid extraction crystallization
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  • 1[1]Matsuda T, Kuroyanagi M, Della G, et al. Cell differen- tiation-inducing diterpene from Andrographis paniculata Nees [J]. Chem Pharm Bull, 1994, 42(6): 1216-1225.
  • 2[2]Kapil A, Koul I B, Banerjee S K, et al. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata [J]. Biochem Pharmacol, 1993, 46(1): 182-185.
  • 3[3]Tripathi G S, Tripathi Y B. Choleretic action of andrographolide obtained from Andrographis paniculata Nees [J]. Phytother Res, 1991, 5(4): 176-184.
  • 4[4]Pan J, Zhu J Z. Separation method for material composition by supercritical fluid crystallization [P]. CN: 1220906A, 1999-06-30.
  • 5[5]Hu X Q, Pan J, Zhang W C, et al. The determination of lactone concentration of andrographlide by RP-HPLC method [J]. J Hefei Univ of Tech-Nat Sci (合肥工业大学学报·自然科学版), 2001, 24(6): 1083-1086.
  • 6[6]Helfgen B, Turk M, Schaber K. Theoretical and experimental investigations of the micronization of organic solids by rapid expansion of supercritical solutions [J]. Powder Technol, 2000, 110: 22-28.
  • 7[7]Krober H, Teipel U. Material processing with supercritical antisolvent precipitation: process parameters and morphology of tartaric acid [J]. J Supercrit Fluid, 2002, 22: 229-235.
  • 8[8]Turk M. Formation of small organic particles by RESS: experimental and theoretical investigations [J]. J Supercrit Fluid, 1999, 15: 79-89.

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