摘要
目的 探讨血小板糖蛋白Ⅱb/Ⅲa受体阻断剂———abciximab对实验性动脉损伤后血管内皮功能的影响。方法 Wistar大白鼠 5 4只 ,随机分为假手术组、对照组和abciximab治疗组 (各 18只 ) ,后两组行腹主动脉内膜剥脱术。abciximab组于术后予abciximab(0 2 5mg/kg)治疗。分别于术后1周、2周和 4周各处死 6只 ,处死前取静脉血测试内皮素、一氧化氮。结果 abciximab治疗组血一氧化氮含量较对照组增高 ,4周后统计学差异无显著性 ;血内皮素水平较对照组有所降低。结论 ab ciximab可改善动脉损伤后血管内皮功能。
Objective To investigate the effect of abciximab on endothelin function of injured artery.Methods Fifty-four rats were divided randomly into artificial group, control group and abciximab group (n=18). We made ballon endothelium denud-ation in abdominal aorta of rats in the latter two groups. The abciximab were injected in abciximab group (0.25 mg/kg). Six rats were respectively killed 1 week, 2 weeks, 4 weeks after operation in each group. Nitric oxide (NO) and endothelium (ET) were obtained before killing. Results NO and ET in abciximab group were lower than in artificial group, control group 4 weeks later. Conclusion Abciximab can improve artery endothelin function after artery injury.
出处
《中国介入心脏病学杂志》
2004年第1期51-52,共2页
Chinese Journal of Interventional Cardiology
