血清TSGF、CEA、CA242、CA19-9联合检测对消化道恶性肿瘤的诊断价值

Combined detection of serum TSGF,CEA,CA242 and CA19-9 in diagnosis of malignant tumors of digestive tract

目的 :探讨恶性肿瘤特异性生长因子 (TSGF)、癌胚抗原 (CEA)、糖抗原 2 4 2 (CA2 4 2 )、糖抗原 1 9 9(CA1 9 9)联合检测对消化道恶性肿瘤的诊断价值。方法 :采用生化或放免分析法检测 2 36例消化道恶性肿瘤患者血清TSGF、CEA、CA2 4 2、CA1 9 9含量 ,与对照组比较 ,并分析结果。结果 :以单一指标阳性作为诊断标准 ,TSGF、CEA、CA2 4 2、CA1 9 9对消化道恶性肿瘤的灵敏度分别为 79.2 4 %、31 .78%、4 2 .80 %、5 5 .5 1 % ;特异度分别为 82 .76 %、97.84 %、98.71 %、92 .2 4 % ;准确度分别为 80 .98%、6 4 .5 3%、70 .5 1 %、73.72 %。联合检测的灵敏度为 90 .2 5 % ,特异度为 72 .4 1 % ,准确度为 81 .4 1 %。结论 :血清TSGF、CEA、CA2 4 2、CA1 9 9联合检测对消化道恶性肿瘤的辅助诊断有较高的临床应用价值。

Objective:To explore the diagnostic value of serum tumor specific growth factor(TSGF),carcinoembryonic antigen(CEA),CA242 and CA19 9 combined in detecting malignant tumors of digestive tract.Methods:The levels of serum TSGF,CEA,CA242 and CA19 9 were determined by biochemical or immunoradiometric assay in patients with malignant tumors of digestive tract and in control group.Results:The sensitivity rates of using single positive diagnostic indicator of TSGF,CEA,CA242 and CA19 9 to malignant tumors of digestive tract were 79.24%,31.78%,42.80% and 55.51 %,respectively.The specific rates were 82.76%,97.84%,98.71% and 92.24%,respectively.The accuracy rates were 80.98%,64.53%,70.51% and 73.72%,respectively.In combined detection,the diagnostic sensitivity rate was 90.25%,the specific rate was 72.41%,and the accuracy rate was 81.41%.Conclusions:Detecting serum TSGF,CEA,CA242 and CA19 9 combinedly is of great clinical value for the diagnosis of malignant tumors of digestive tract.