妊娠高血压综合征患者胎盘组织中VCAM-1的表达及意义

On the Expression and Meaning of Placenta Tissue VCAM-1 in Pregnancy Induced Hypertension

目的 :研究血管细胞粘附分子VCAM 1在妊娠高血压综合征 (PIH)胎盘组织中的表达 ,以探讨其在PIH发生发展中的作用。方法 :应用免疫组化Envision法检测了 32例PIH患者及 38例正常妊娠晚期胎盘组织中VCAM 1的表达。结果 :VCAM 1主要表达在胎盘滋养叶细胞及血管内皮细胞 ;PIH患者胎盘滋养叶细胞表达率为18 75 % ,低于正常妊娠晚期的 6 3 16 %。而血管内皮细胞表达率为 4 3 75 % ,高于正常妊娠晚期的 2 6 32 %。结论 :PIH患者胎盘滋养层细胞缺乏VCAM的表达可能与PIH发生发展有关。

Objective: To discuss the expression of the endothelial cell adhesion molecule VCAM-1 on the placenta tissue in the case of pregnancy induced hypertension (PIH) and its effect on the start and development of PIH. Methods: The different expression of VCAM-1 in the placenta tissue between 32 PIH patients and 38 normal ones in later period of pregnancy was detected by means of immunity envision. Results: VCAM-1 was mainly expressed in the placental cytotrophoblasts and the endovascular cells; The expressive rate of placental cytotrophoblasts in PIH patients was 18.75%, which was lower than that (63.160%) in normal ones in later period of pregnancy, while the expressive rate of endovascular cells in the PIH patients (43.75%) was higher than that (26.32%) in normal ones in later period.Conclusion: It was possible that there was some relationship between the start and development of PIH and lacking of the VCAM expression in the placental cytotrophoblasts of PIH patients.