不同类型高脂血症患者血清sVCAM-1测定的临床意义

The Clinical Meaning of Measuring of Serum sVCAM-1 in Different type Hyper-lipemia

目的 :探讨血清可溶性血管细胞黏附分子 (sVCAM 1)浓度在不同类型高脂血症中的临床意义。方法 :应用酶联免疫吸附 (ELISA)法测定 6 6例不同类型高脂血症患者血清sVCAM 1的浓度 ,与正常对照组比较。结果 :高胆固醇组、高胆固醇高甘油三酯组 ,其血清sVCAM 1浓度分别为 (999 81± 16 5 0 3)ng/ml、(10 5 5 4 2± 14 8 6 4 )ng/ml,均高于正常对照组 (P <0 0 1) ,而高甘油三酯组血清sVCAM 1为 (85 1 32 +170 5 9)ng/ml,虽高于正常对照组 (P <0 0 5 )。但均低于高胆固醇组和高胆固醇高甘油三酯组 (P <0 0 1) ,高胆固醇组与高胆固醇高甘油三酯组的血清sV CAM 1浓度比较未显示统计学意义 (P >0 0 5 )。结论 :高脂血症患者血清sVCAM 1浓度高于正常对照组 ,不同类型高脂血症患者血清sVCAM 1浓度不同 ,因此 ,血清sVCAM 1可作为评价动脉粥样硬化危险性的血清学指标之一。

Objective: To explore the clinical meaning of the concentration of serum sVCAM-1 in different type hyper lipemia. Methods:To measure the concentration of serum sVCAM-1 of 66 patients in diffent type of hyperlipemia by ELISA and compare with normal man. Results:High cholesterol group,high cholesterol and high triglycerides group, their concentrations of serum sVCAM-1 were as follows:(999.81±165.03)ng/ml,(1 055.42±148.64)ng/ml.All were higher than normalcompared group(P<0.01), while serum sVCAM-1 concentration of high triglycerides group was (851.32±170.59)ng/ml, although higher than normal control group(P<0.05), but all lower than high cholesterol group and both cholesterol and triglycerides high group. The serum sVCAM-1 concentration hed not significant difference(P>0.05) between high cholesterol group, and both cholesterol and triglycerides high group.Conclusion: The serum sVCAM-1 concentrtion of hyperlipemia patients was higher than normal man.In different type hyperlipemia patient the serum sVCAM-1 concentrtion was different too.Therefore, the serum sVCAM-1 can be used as one of the serum significance to evaluate the danger of atherosclerosis.