摘要
目的 对复方甘草甜素和干扰素 α-1b治疗慢性乙型肝炎进行经济学评价 ,为临床提供最佳用药方案。 方法 采用随机分组对照进行临床实验观察 ,分析比较复方甘草甜素与干扰素α-1b的治疗成本和治疗效果。结果 复方甘草甜素和干扰素α-1b治疗慢性乙型肝炎的总有效率分别为 71.67%和 66.67% ( P>0 .0 5 ) ;成本 -效果比分别为 83 .0 8和 12 5 .69( P<0 .0 5 ) ;经敏感度分析所得的成本 -效果比分别为 70 .62和10 6.83。 结论 复方甘草甜素与干扰素 α-1b均能有效治疗慢性乙型肝炎 ,但前者比后者更经济 ,更符合药物经济学原则。
OBJECTIVE To evaluate pharmacoeconmics of Glycyrrhizin and Interferon α-1b in theatment of Chronic hepatitis B.METHODS Using pharmacoeconomic cost-effectiveness analysis ,Interferonα-1b was compered with Compound Glycyrrhizin in the treatment of 120 patients with Chronic hepatitis B(divided into two groups randomly).RESULTS After treatment the effective rates of Compound Glycyrrhizin and Interferon α-1b were 71.67% and 66.67%(P>0.05);the cost-effectiveness ratios were 83.08 and 125.69respectively(P<0.05).Cost-effectiveness ratios obtained by seneitivity analysis were 70.62 and 106.83 respectively.Cost-effectiveness ratios obtained by seneitivity analysis were 70.62 and 106.83 respectively.CONCLUSION In treatment of Chronic hepatitis B,Compound Glycyrrhizin is more economical than Interonα-1b.
出处
《海峡药学》
2004年第1期99-101,共3页
Strait Pharmaceutical Journal
