米索前列醇用于宫腔镜检查的临床观察

THE APPLICATION OF MISOPROSTOL IN HYSTEROSCOPIC EXAMINATION

目的 :临床观察米索前列醇在宫腔镜检查时宫颈软化及止痛效果。方法 :12 0例宫腔镜检查随机分为两组 ,米索组 6 5例检查前 3小时阴道置米索 4 0 0 μg ;对照组 5 5例 ,检查前 3小时阴道置灭滴灵 0 .4 g。结果 :米索组常规宫腔镜检查时人工流产综合征 (PAAS)发生率仅为 3.1% ,对照组为 2 0 .0 % ,诊刮或取环时米索组PAAS发生率为 8.8% ,对照组为 4 5 .2 % ,米索组明显低于对照组。VAS评分米索组无痛苦者 12 .3% ,轻痛者 2 4 .6 % ,中痛者 5 0 .8% ,剧痛者 12 .3% ;对照组无痛者 0 ,轻痛者 12 .7% ,中痛者 4 1.8% ,剧痛者 4 5 .5 % ,两组差别有显著性。结论 :宫腔镜检查前3小时一次性阴道内置米索 4 0 0 μg ,为方便、有效并充分软化宫颈的理想方法 ,可明显缓解有创检查和治疗时的疼痛 ,值得推广应用。

Objective: To observe the effects of misoprostol on cervical soften and paregoric in hysteroscopic examination. Methods:A total of 120 patients were divided into two groups randomly, 65 patients in the test group in the which the misoprostol 400μg was given 3 hours before exam; 55 patients in the controlled group used vaginal flagyl. Results: In the test group the PAAS (post artificial abortion syndrome) rate was only 3.1% during hysteroscopic exam, 20.0% in controlled group; and the PAAS rate during D&C and removal IUD was 8.8% and 45.2% respectively. The PAAS rate was lower in the test group than that in the controll. 12.3% patients had no pain, 24.6% patients had mild pain, 50.8% had medium pain and 12.3% had pang in the test group on the basis of VAS scoring. 12.7% had moderate pain, 41.8% had medium pain and 45.5% had pang in the control group. There is significant difference between two groups. Conclusion:It is an ideal way that application of vaginal misoprostol 400ug 3 hours before hysteroscopic exam. It is simple and effective for softening cervix and remission pain.