左氧氟沙星与头孢硫脒合用对金黄色葡萄球菌 表皮葡萄球菌 粪肠球菌体外抗菌活性研究

The Study on the Antibacterial Activity of Cefathiamidine Combined with Levofloxacin Against Staphylocococcus Aureus Staphtcococcus Epidermidis and Enterococcus Faecal

目的 评价左氧氟沙星与头孢硫脒联合应用对金黄色葡萄球菌、表皮葡萄球菌和粪肠球菌的体外联合抗菌作用。方法 采用棋盘法设计 ,微量肉汤稀释法测定其MIC值 ,计算FIC指数。结果 左旋氧氟沙星与头孢硫脒联合应用后 ,左旋氧氟沙星对金黄色葡萄球菌、表皮葡萄球菌、粪肠球菌、MRSA、MRSE的MIC50 均有明显降低。同样 ,头孢硫脒对金色葡萄球菌、表皮葡萄球菌、粪肠球菌、MRSA、MRSE的MIC50 亦显著下降。FIC指数范围主要在 0～ 1。结论 左氧氟沙星与头孢硫脒药物联合应用 ,对金黄色葡萄球菌。

Aim To evaluate the antibiotic effects of Cefathiamidine combined with Levofloxacin against Staphylocococcus aureus Staphtcococcus epidermidis and Enterococcus faecalis.Methods The protocol was designed by checkerboard method and the MICs of Cefathiamidine alone combined with Levofloxacin against Staphylocococcus aureus Staphtcococcus epidermidis and Enterococcus faecalis were determined by broth dilution method,the FIC index was calculated according to MIC results.Results When Cefathiamidine combined with Levofloxacin,The MIC 50 of Levofloxacin against Staphylocococcus aureus,Staphtcococcus epidermidis and Enterococcus faecalis were reduced significantly.The MIC 50 of Cefathiamidine against the test bacteria were reduced significantly also.The range of the FIC index was mainly between 0～1.Conclusion The results suggested that synergism and additivity of Cefathiamidine combined with Levofloxacin respectively against Staphylocococcus aureus Staphtcococcus epidermidis and Enterococcus faecalis were main action.