黄芪与维生素E对肢体缺血再灌注损伤的保护作用

Protective effect of Radix Astragali(Astragalus root) and vitamin E on ischemic reinfusion injury of limbs in rabbits

目的 :探讨黄芪与维生素 E对肢体缺血再灌注损伤有无保护作用 ,为指导临床用药提供理论依据。方法 :复制家兔缺血再灌注损伤模型 ,采用生化分析方法测定血清天冬氨酸氨基转移酶 ( AST)、肌酸激酶 ( CK)、丙二醛 ( MDA)、超氧化物歧化酶 ( SOD)的含量。结果 :黄芪与维生素 E治疗组 AST、CK、MDA水平较缺血再灌注组显著下降 ( P<0 .0 5 ) ,SOD显著升高 ( P<0 .0 5 )。结论 :黄芪与维生素

Objective:To discuss the protective effect of Radix Astragali and vitamin ischemic reinfusion jujury of limbs and support theoretinal basis for clinical dosage.Methods:To replicate rabbit ischemic reinfusion injury model.The levels of aspartate aminotrans ferase (AST), creative phosphokinase (CK),malondialdenhyde (MDA) and superoxidedismatase (SOD) were measured by biochemical methods.Results:The levels of AST,CK and MDA in drug group were significantly lower than that in model group ( P <0.05),but the level of SOD higher ( P <0.05).Conclusion:Radix Astragali and vitamin E have lignificant protective effect for ischemic reinfusion injury of limbs.