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甲状腺过氧化物酶B细胞抗原决定簇研究进展 被引量：3

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摘要 甲状腺过氧化物酶(TPO)作为一种重要的甲状腺自身抗原,在自身免疫性甲状腺疾病(AITD)的发病机制中占有重要地位。大多数TPO-B细胞抗原决定簇是高度构象性的,并集中于一个有限的区域——免疫优势区(IDR)中,而TPO表位“指纹”也具有一定的指导意义。IDR定位仍不清楚,可能主要由TPO中MPO样区与CCP样区相接的区域高度折叠而构成。TPO中也存在少量的非IDR B细胞抗原决定簇和线性决定簇。TPO-B细胞抗原决定簇及IDR构成、分布、定位等问题的解决很可能有助于阐明AITDs的发病机制,并为开辟特异性分子治疗途径提供理论基础。
作者 刘金泉 孙楠 方佩华 冯凭
机构地区 天津医科大学总医院内分泌科 天津医科大学总医院内分泌科核医学科
出处 《国外医学（内分泌学分册）》 2004年第2期113-116,共4页 Foreign Medical Sciences(Section of Endocrinology)
关键词 甲状腺过氧化物酶 B细胞抗原决定簇 研究进展 自身免疫性甲状腺疾病 免疫优势区
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献17

  • 1Pichurin P,Guo J,Estienne V,et al.Evidence that the complement control protein-epidermal growth factor-like domain of thyroid peroxidase lies on the fringe of the immunodominant region recognized by autoantibodies.Thyroid,2002,12:1085-1095.
  • 2Estienne V,Duthoit C,Blanchin S,et al.Analysis of a conformational B cell epitope of human thyroid peroxidase:identification of a tyrosine residue at a strategic location for immunodominance.Int Immunol,2002,14:359-366.
  • 3Guo J,McLaChlan SM,Rapoport B.Localization of the thyroid peroxidase autoantibody immunodominant region to a junctional region containing portions of the domains homologous to complement control protein and myeloperoxidase.J Biol Chem,2002,277:40189-40195
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同被引文献17

  • 1薛声能,雷娟,刘顺莲.血清TRAb测定在Graves病诊治中的临床意义的探讨[J].国际医药卫生导报,2005,11(24):22-23. 被引量：5
  • 2李玉姝,赵冬,单忠艳,滕晓春,滕笛,关海霞,于晓会,范晨玲,崇巍,杨帆,戴红,谷晓岚,于扬,毛金媛,李佳,陈彦彦,杨榕,姜雅秋,李晨阳,滕卫平.不同碘摄入量地区甲状腺自身抗体的流行病学五年随访研究[J].中华内分泌代谢杂志,2006,22(6):518-522. 被引量：29
  • 3Karanikas G,Schuetz M,Wahl K,et al.Relation of antiTPO autoantibody titre and T-lymphocyte cytokine production patterns in Hashimoto's thyroidities[J].Clin Endocrinol(Oxf),2005,63(2):191-196.
  • 4Heufelder A E.Pathogenesis of Graves' ophthalmopathy:recent controversies and progress[J].Eur J Endocrinol,1995,132(5):532-541.
  • 5范玮.自身免疫与自身免疫病[M]//龚非力.医学免疫学.第2版.北京:科学出版社,2004:316-336.
  • 6Ghoraishian SM, Hekmati Moghaddam SH, Afkhami- Ardekani M. Relationship between anti-thyroid peroxidase antibody and thyroid function test[J]. Iran J Immunol,2011,3(3) : 146-149.
  • 7Eckstein A, Mann K,Kahaly GJ,et al. Role of TSH receptor autoantibodies for the diagnosis of Graves disease and for the prediction of the course of hyperthyroidism and ophthalmopathy[J]. Med Klin (Munich), 2009, 104 (5) :343-346.
  • 8Laurberg P,Wallin G,Tallsted L, et al. TSH-receptor autoimmunity in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine : a 5-year prospective randomized study[J]. Eur J Endocrinol, 2008,158( 1 ): 69-73.
  • 9Karanikas G, Schuetz M,Wahl K, et al. Relation of antiTPO autoantibody titre and T-lymphocyte cytokine production patterns in nashimoto's thyroidities[J]. Clin Endocrinol(Oxf) ,2005,63(2) : 191-196.
  • 10宋武战,池君,汪静.促甲状腺激素受体抗体(TRAb)测定的临床价值[J].放射免疫学杂志,2007,20(5):399-401. 被引量：33

引证文献3

二级引证文献41

国外医学（内分泌学分册）
2004年 第2期

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