摘要
西维来司钠是新近研究成功的弹性蛋白酶抑制药 ,对实验性急性肺损伤具有良好的保护作用。其作用机制不同于现有的类固醇激素药物 ,可能是西维来司钠选择性抑制弹性蛋白酶 ,抑制肺泡炎症细胞浸润 。
Sivelestat is a newly developed elastase inhibitor which has been shown to have good protective effect on the lung tissue during acute experimental pulmonary injury. The underlying mechanisms of its effect are different from those of steroid drugs now available. It seems possible that sivelestat may be capable of selectively inhibiting elastase and depressing infiltration of inflammatory cells in the alveoli, and thereby exerting protective effects on vascular endothelium and pulmonary tissues injured by elastase.
出处
《医药导报》
CAS
2004年第4期207-209,共3页
Herald of Medicine
基金
国家 8 63计划项目(基金编号:2 0 0 1AA2 3 40 2 1)
国家 973计划项目(基金编号:G19980 5 112 0 )
国家自然科学基金项目(基金编号:3 0 171148
3 0 0 1161940 )
